Muse Watson was born in Alexandria, Louisiana and attended Louisiana Tech on a music stipend for two years before transferring to Berea College, Berea, Kentucky, where he performed for the first time on stage as Petruchio in "Taming of the Shrew". During and after his years at Berea, he worked in outdoor dramas, dinner theaters, and small repertory groups before going on to pursue a career in film.
His theater credits include Hamlet in "Hamlet", Stanley in "A Streetcar Named Desire", Pale in "Burn This", Cervantes in "Man of La Mancha", and directing "Ain't MisBehavin". In 1989, with a new commitment to acting, Muse began pursuing roles in feature film. By 2010, he had appeared in 51 feature length films sharing scenes with Julia Roberts, Jason Robards, Jon Voight, Robert Duvall, Jennifer Love Hewitt, Don Cheadle, Richard Gere, Sylvester Stallone, Robert Patrick, Hilary Swank, Kiefer Sutherland and Richard Gere. In television, he appeared as the wise Charles Westmoreland/DB Cooper in the award winning first season of Prison Break (2005) with Wentworth Miller and 11 episodes of NCIS (2003) as Mark Harmon's mentor. Muse also gave an unforgettable performance with Jennifer Love Hewitt as a special guest on Saturday Night Live. Muse and his wife and daughter now divide their time between their home in Los Angeles and their "hide-out" in the foothills of the Smoky Mountains.